Open Postdoctoral Position in Bioinformatics
The Peters Lab at the La Jolla Institute for Immunology (LJI) is seeking highly motivated and accomplished scholars to join their interdisciplinary group of researchers working in profiling immune responses in infectious diseases, such as M. tuberculosis, B. Pertussis, and SARS-CoV-2. Successful candidates will be immersed in projects on a collaborative team of experimental and computational scientists working towards understanding, preventing, and curing infectious diseases.
Areas of research may include the following:
- M. tuberculosis: Around 2 billion individuals are infected with Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Despite the relative low lifetime risk of latently infected individuals developing active disease, it has been estimated that 80% of new cases of TB are due to reactivation of latent disease. In hoping to meet the World Health Organizations goals of TB eradication, our aim is to develop an efficient diagnostic test that can predict which individuals are likely to progress to active TB.
- B. Pertussis: In the mid-1990s, concerns over vaccine-related side effects prompted the replacement of the whole-cell Pertussis (wP) vaccine in favor of a safer acellular Pertussis (aP) vaccine. Recently, there has been a worldwide reemergence of Pertussis (whooping cough) despite widespread vaccination. Our approach is to compare individuals born before 1995 and vaccinated in infancy with wP, with individuals born in 1996 or later and vaccinated with aP in infancy. We hope to identify the cascade of immune events following Pertussis booster vaccination, and to identify correlates of long-lasting vaccine-induced immunity.
- Covid-19: In the face of the current coronavirus pandemic, it is important to understand how the virus affects the human immune system. We are aiming to understand which antibodies are most effective against the novel coronavirus SARS-CoV-2, in order to help antibody-based therapeutics needed to fight against this escalating threat.
The ideal candidate will have extensive skills/knowledge in at least 2 of the following areas:
- Experimental data analysis—RNA-Seq, flow/mass cytometry, single cell analysis Immunology—adaptive immunity and epitope recognition
- Data analysis techniques—statistics, data visualization, machine learning
- Software development—programming in Python preferred, or proficiency in other programming languages; Unix Shell; version control
- Knowledge representation—database systems, RDF/OWL, OBO ontologies
- Ability to independently drive projects
- Candidates holding PhD and/or MD degrees are welcomed to apply
- Non-US residents/citizens are welcomed to apply
Appointment term is typically 2-5 years.
Start date is flexible until positions are filled.
Please submit a Curriculum vitae (CV) and cover letter and indicate one or more potential matches to the specific projects from above. Responsibilities and position specifics will depend on the candidate’s skills/qualifications. Applications without a cover letter will not be reviewed.
In 2017 and in 2019, LJI was ranked as one of the best places to work in San Diego by the San Diego Business Journal. LJI is located in the Science Research Park on the campus of UC San Diego, with easy access to the San Diego life sciences community and the La Jolla area has to offer. Full-time employment at LJI includes a competitive salary, medical/dental/vision benefits, paid vacation/sick leave, and contributions to a (403b) retirement plan.